| 제목 |
A genome-wide scan for the Sasang constitution in a large Korean family suggests significant linkage at chromosomes |
| 등록일 |
2015-12-09 |
첨부파일 |
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| 구분 |
SCI |
| 학술지 |
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE |
| 발표일 |
2009-07-08 |
| 저자 |
이시우, 원홍희, 김종원, 장은수, 김가영, 박영규, 김영주, 김용성, 김부여, 김종열 |
Objectives: We aim to identify the genetic loci responsible for Sasang constitution type, which is important for effective personalized treatments in traditional Korean medicine.
Subjects: Forty (40) individuals in a Korean family were recruited for linkage analysis and 310 unrelated individuals for association analysis to confirm the linkage result.
Outcome measures: Genome-wide linkage analysis was performed for the Korean family using the Affymetrix 500K arrays. MERLIN software was used for multipoint nonparametric linkage (NPL) analysis. The significant candidate regions in linkage analysis were also investigated with association analysis of independent 310 individuals.
Results: Linkage analysis showed four significant peaks, 3q27.3, 8p11.21, 8q11.22–23, and 11q22.1–3, whose NPL Z scores are greater than 5.0. Among the significant loci, the 8q11.22–23 and 11q22.1–3 regions were supported by independent association analysis at the level of p < 0.05.
Conclusions: The 8q11.22–23 and 11q22.1–3 regions were suggested as the candidate region for significant linkage to Sasang constitution.
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