| 제목 |
Genetic effects of FTO and MC4R polymorphism on body mass in constitutional types |
| 등록일 |
2015-12-09 |
첨부파일 |
|
| 구분 |
SCI |
| 학술지 |
Evidence-based Complementary and Alternative Medicine |
| 발표일 |
2009-09-13 |
| 저자 |
차성원, 김종열, 구임회, 박병래, 정상균, 최선미, 김길수, 신형두 |
Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings
into four types through states of physiological imbalances and responsiveness to herbal medicine.
One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance
toward preserving energy. Common variants of fat mass and obesity associated (FTO) and
melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index
(BMI) by affecting energy intake. Here, we statistically examined the association of FTO and
MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM
typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle
intervention. The increased BMI replicated the association with FTO haplotypes (effect size
’1.1 kg/m2) and MC4R variants (effect size ’0.64 kg/m2). After the lifestyle intervention, the
carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose
more waist-to-hip ratio (0.76%) than non-carriers. The constitutional discrepancy for the accumulation
of body mass by the effects of FTO and/or MC4R variants seemed to reflect the
physique differences shown in each group of SCM constitutional types. In conclusion, FTO and
MC4R polymorphisms appear to play an important role in weight gain, while only FTO
variants play a role in weight loss after lifestyle intervention. Different trends were observed
among individuals of SCM types, especially for weight gain. Therefore, classification of individuals
based on physiological imbalance would offer a good genetic stratification system in
assessing the effects of obesity genes. |
